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International Affairs Students Current Students Alumni Faculty/Staff Careers--> TOHOKU UNIVERSITYCREATING GLOBAL EXCELLENCE Search 日本語 Contact Tohoku University --> --> About Facts & Figures Facilities Organization Chart History President's Message Top Global University Project Designated National University Global Network Promotional Videos Academics Undergraduate Graduate Courses in English Exchange Programs Summer Programs Double Degree Programs Academic Calendar Syllabus Admissions Undergraduate Admissions Graduate Admissions Fees and Expenses Financial Aid Research Feature Highlights Research Releases University Research News Research Institutes Visitor Research Center Research Profiles Academic Research Staff Campus Life International Support Office IT Services Facilities Dining & Shops Campus Bus Clubs & Circles News University News Research--> Arts & Culture Health & Sports Campus & Community Press Release--> International Visit Alumni Careers Events Exhibits Music Special Event Lecture Alumni--> Map & Directions Campus Maps & Bus--> Facilities Map--> TOHOKUUNIVERSITY About Academics Admissions Research Campus Life News Events International Affairs Students Current Students Alumni Faculty/Staff Promotional Videos Subscribe to our Newsletter Map & Directions Contact Jobs & Vacancies Emergency Information Site Map 日本語 Close Home News Research In Vivo Skin Imaging Technology Developed News In Vivo Skin Imaging Technology Developed 2018-10-11 Research Simultaneous Dual-Wavelength Photoacoustic & Ultrasound Images A Research and Development group led by Professor Yoshifumi Saijo of Tohoku University and Noriyuki Masuda of Advantest has succeeded in developing in vivo skin imaging technology [1] that can simultaneously generate dual-wavelength photoacoustic images and ultrasound images. The research is part of the "Innovative Visualization Technology to Lead to Creation of a New Growth Industry" project operated by Takayuki Yagi and supported by the Impulsing Paradigm Change through Disruptive Technologies Program (ImPACT), run by Japan's Council for Science, Technology and Innovation. Photoacoustic imaging [2] is a method of imaging the interior of a living body by irradiating light into the body and measuring ultrasonic waves generated from blood or tissues that selectively absorb light energy. The technology is attracting interest as a new noninvasive imaging method suitable for measuring small blood vessels in the skin, which is difficult to see using conventional imaging techniques. The principle of photoacoustic imaging (left) and ultrasonic imaging (right) using a focused ultrasonic sensor. Copyright: Tohoku University. However, when using only photoacoustic imaging, even if microvessels in the skin measuring several tens of microns or less in diameter are imaged, it is impossible to ascertain which region of each layer of the skin they are in. In addition, it is possible to photoacoustically measure the oxygen saturation level of blood vessels [3] by using light sources of multiple wavelengths, but the movement of living bodies affects measurement results, so the use of this method has been limited to research applications such as animal experiments. The newly developed in vivo imaging technology utilizes a focused ultrasonic sensor that can detect multiple ultrasonic signals. The photoacoustic waves and ultrasonic waves can be measured with the same sensor, while signals are generated on two alternating wavelengths, allowing the detection of ultrasonic waves that image the microvascular network in the dermis as well as blood oxygen saturation. Example of forearm skin imaging. Blue indicates lower oxygen saturation of blood vessels, red higher. Copyright: Tohoku University. A 6 mm square area of 2 mm depth can be imaged in around 4 minutes. Also using the acquired data, mapping of oxygen saturation and the superposition of photoacoustic images and ultrasound images is possible. Biopsy studies have proved that signs of skin aging such as spots and wrinkles are related to microvessels in the skin. The newly developed photoacoustic imaging method is expected to be used for monitoring of photoaging of the skin as well as in other applications. Block Diagram of New System. Copyright: Advantest Corporation Reference: (1) In vivo imaging: Imaging of a living body (2) Photoacoustic imaging: A method of detecting and imaging the ultrasonic waves generated by thermal expansion of an absorber that absorbs light (a phenomenon known as the photoacoustic effect) by irradiating the absorber with a pulsed laser beam. (See figure at right.) (3) Oxygen saturation: The proportion (%) of oxygenated hemoglobin of total hemoglobin in the blood. In photoacoustic imaging, we can calculate oxygenated hemoglobin concentration and de-oxygenated hemoglobin concentration from acoustic pressures obtained at two wavelengths to calculate oxygen saturation. News in Japanese For enquiries about this press release: Graduate School of Biomedical Engineering, Tohoku UniversityE-mail: bme-prgrp.tohoku.ac.jpTel: +81-22-795-7491 For enquiries about the research: Professor Yoshifumi SaijoGraduate School of Biomedical Engineering, Tohoku UniversityE-mail: saijotohoku.ac.jpTel: +81-22-795-7148 Category University News Research Arts & Culture Health & Sports Campus & Community International Visits Alumni Careers COVID-19 Archives 2014&＃24180; 2015&＃24180; 2016&＃24180; 2017&＃24180; 2018&＃24180; 2019&＃24180; 2020&＃24180; 2021&＃24180; 2022&＃24180; 2023&＃24180; 2024&＃24180; Recent News 2024-04-10 University News Tohoku University&＃039;s New President Meets the Media 2024-04-10 Careers Recruitment Notice: Associate Professor 2024-04-03 University News Tohoku University Entrance Ceremony, Spring 2024 2024-04-02 Careers Recruitment Notice: Assistant Professor 2024-04-01 University News In Conversation with Hideo Ohno Archives Page Top About Tohoku University Academics Admissions Research Campus Life News Events International Affairs Students Alumni Promotional Videos Subscribe to our Newsletter Map & Directions Contact Tohoku University Jobs & Vacancies Emergency Information Site Map Privacy Policy Media Enquiries Parent & Family Support Public Facilities Contact Tohoku University