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About Mission and Outline Background Activities For Community Message from Executive Director Toward the Development of Personalized Healthcare through the Promotion of Industry-Academia Collaboration Organization and Members Department of Community Medical Supports Department of Preventive Medicine and Epidemiology Department of Biobank Department of Integrative Genomics Department of Health Record Informatics Department of Education and Training Department of Public Relations and Planning General Affairs and Planning Sector Cohort Studies Sector Integrated Biobank Sector Integrated Omics Sector Group of Planning Group of Public Relations Group of Education and Training Group of Return of Genomic Results Center for Promotion of Cohort Studies Center for Health Survey Promotion Group of Brain Imaging and Research Group of Biobank Center for Biobank Utilization and Academia-Industry Partnership Group of Integrated Database Systems Group of Information Management for Genome-Cohort Study Group of Privacy Controls Group of Sequencing Group of Microarray-based Genotyping Group of Metabolomics Group of Metagenomics and Microbiome Group of Omics Data Analysis Center for Genome-Wide Association Study Office of Nihonbashi Branch Operation Center for Genome Platform Projects Policy Site Policy Social Media Policy Research Cohort Study and Biobank Community-Based Cohort Study (TMM CommCohort Study) Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study) Integrative Genomics Publications Facilities and Equipment Researchers Specimen and Data Collection Ethical Issues ToMMo's Library News Timeline sitemap links access & contact JAPANESE Large Small A A Top ResearchIdentified Nicotinamide Mononucleotide (NMN) in Breast Milk as an Important Nutritional Ingredient for Child Neurodevelopment Study Published in the International Journal Nutrients News Timeline all News Events Research Monthly archives 2024, April 2024, February 2024, January 2023, November 2023, October 2023, September 2023, August 2023, July 2023, June 2023, May 2023, April 2023, March 2023, January 2022, December 2022, November 2022, October 2022, September 2022, July 2022, May 2022, April 2022, January 2021, December 2021, November 2021, September 2021, August 2021, July 2021, June 2021, March 2021, January 2020, November 2020, October 2020, September 2020, August 2020, July 2020, June 2020, April 2020, March 2020, February 2020, January 2019, December 2019, November 2019, September 2019, August 2019, July 2019, May 2019, April 2019, March 2019, February 2019, January 2018, December 2018, November 2018, October 2018, September 2018, August 2018, July 2018, June 2018, May 2018, March 2018, February 2018, January 2017, December 2017, November 2017, October 2017, September 2017, August 2017, July 2017, June 2017, May 2017, March 2017, February 2017, January 2016, December 2016, November 2016, October 2016, September 2016, August 2016, July 2016, June 2016, May 2016, April 2016, March 2016, February 2016, January 2015, December 2015, November 2015, October 2015, September 2015, August 2015, July 2015, June 2015, May 2015, April 2015, March 2015, February 2015, January 2014, November 2014, October 2014, August 2014, July 2014, April 2014, March 2014, February 2014, January 2013, November 2013, August 2013, July 2013, June 2013, May 2013, April 2013, February 2013, January 2012, December 2012, November 2012, October 2012, September 2012, April 2012, March 2012, February Identified Nicotinamide Mononucleotide (NMN) in Breast Milk as an Important Nutritional Ingredient for Child Neurodevelopment Study Published in the International Journal Nutrients Research: 2024/01/29 Joint research with ToMMo and Meiji Co., Ltd. has resulted in identifying the concentration of nicotinamide mononucleotide (NMN)*1, a nutrient contained in breast milk, is an important nutritional ingredient related to the neurodevelopment of infants raised on breast milk. The findings of this research have been published in the international journal “Nutrients”. Summary of the Findings (1) Nicotinamide mononucleotide (NMN) was quantified as the major NAD precursor in breast milk. As a result, NMN had the highest concentrations in breast milk among the NAD-related substances. (2) The NMN concentration in breast milk was the only NAD-related substance in breast milk that showed a significant positive correlation with neurodevelopmental outcome in children. Background and Outlook The so-called first 1000 days, spanning the prenatal period to 2 years after birth, constitute the most significant period of neurodevelopment. Nutritional deficiencies during this period can have long-term and often irreversible effects on neurodevelopmental outcome. However, few studies have examined the relationship between breast milk micronutrients and infant neurodevelopmental outcome. In the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study, breast milk samples were gathered and used to measure the concentrations of multiple nutrients related to a type of vitamin known as niacin*2 and analyze the correlation to child neurodevelopment metrics. As a result, it was discovered that nicotinamide mononucleotide concentration showed a significant positive correlation with neurodevelopmental outcome at the age of two years for infants (ASQ-3 Score)*3. In this study, biobank breast milk samples were used to measure niacin-related compounds, identifying NMN as one of the elements related to infant neurodevelopment. These results are expected to serve as knowledge that contributes to better growth and development for babies and infants.   *1. A precursor of nicotinamide adenine dinucleotide (NAD+). Promoting the generation of NAD+ supports cellular energy generation and metabolic activity. *2. A type of vitamin B group. In addition to supporting the metabolism of lipid and amino acids in the body, this also serves as a coenzyme related to redox reactions. Found in plentiful amounts in foods such as chicken breast, pork, mackerel, pike, yellowtail, and cod roe. *3. Age & Stages Questionnaires®, Third Edition. The ASQ-3 is used to screen infants aged 1–66 months for risk of developmental delay in five developmental domains: communication, gross motor, fine motor, problem solving, and personal-social. For each domain, six questions to parents are used to assess achievements in the associated skills of children. The ASQ-3 scores consisted of values of 0–60, in increments of 5 points.   Publication Details Title: Effect of Nicotinamide Mononucleotide Concentration in Human Milk on Neurodevelopmental Outcome: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study Authors: Yoshie Saito, Keigo Sato, Shinji Jinno, Yoshitaka Nakamura, Takahiro Nobukuni, Soichi Ogishima, Satoshi Mizuno, Seizo Koshiba, Shinichi Kuriyama, Kinuko Ohneda, Masashi Morifuji Journal: Nutrients Published date: December 31, 2023 DOI: 10.3390/nu16010145 News Timeline Tweet About Mission and Outline Background Activities For Community Message from Executive Director Organization and Members Policy Research Cohort Study and Biobank Integrative Genomics Publications Facilities and Equipment Researchers Ethical Issues Specimen &＃038; Data Collection ToMMo's Library News Timeline access & contact sitemap links JAPANESE Large Small A A Copyright(C) Tohoku University Tohoku Medical Megabank Organization All Rights Reserved. sitemap access & contact About Research Ethical Issues Specimen &＃038; Data Collection ToMMo's Library News Timeline access & contact sitemap links Japanese