スポーツベットアイオーの競馬の賭け方を徹底解説【最新版】

Skip to main content Site search Researcher Search close CLOSE search menu グローバルナビゲーション（英語） About Message from the President Operations and future plans History Facts and Figures Awards and honors University profile Living in Kyoto Public relations Employment Human rights Gender equality Health, safety, and environment Kyoto University from a Global Perspective Study at KyotoU Education and admissions Career paths Visa/tuition/scholarships/housing University facilities FAQ Research & Collaborate Research news and departments Policies Collaboration Research support and scholarships Careers Visa/Housing/Daily Life About Research compliance & ethics Global KyotoU International strategy Global profile Global partners International risk & crisis management Global University Social Responsibility KyotoU International Concierge and information resources ヘッダー プライマリーリンク（英語） Current Students & Staff Alumni ヘッダー セカンダリーリンク（日本語以外） Events Directions Contact Make a gift Language 日本語 ホーム English Home 中文简体 首页 中文繁体 首頁 한국어 홈페이지 Breadcrumb Home RESEARCH NEWS Sting operation out of gas Sting operation out of gas In other languages 日本語 Doubts about whether micronuclei activate cGAS-STING pathway ターゲット Corporations & Researchers Published on 2024/03/13 Kyoto, Japan -- Cells possess an innate immune system that defends against invasive pathogens such as bacteria and viruses. Previous studies have mapped out the cytoplasmic cGAS-STING pathway in the cytoplasm, known for responding to foreign nucleic acids, such as double-stranded DNA. Micronuclei -- or MN, abnormal intracellular structures containing the cell's DNA -- have also been suspected of triggering the pathway. However, no conclusive evidence exists of pathway activation by MN-induced cyclic GMP-AMP synthase, or cGAS. Now, Kyoto University and the AIRC Institute of Molecular Oncology, or IFOM, have collaborated to develop the reporter cell line Fusion Visualization system 2 -- FuVis2 -- designed to help researchers visualize cellular nuclei with chromosome fusion and resulting MN. Using FuVis2, they examined whether MN influences the cGAS-STING response in live cells, where STING refers to stimulators of interferon genes. "Our findings suggest cGAS more commonly recognizes MN during cell division without activating STING in the following cell cycle, contrary to the existing theory that cGAS-bound MN leads to STING activation," says lead author Makoto Hayashi at the IFOM-KU Joint Research Laboratory at KyotoU's Graduate School of Medicine. The team also showed that cGAS-STING activation by gamma irradiation leads to mitochondrial DNA leakage into the cytoplasm and is not associated with MN formation. The observed MN inactivity against innate immune responses may suggest chromosomal abnormalities with severe consequences. Radiation-generated MN had been reported to activate the cGAS-STING pathway, so the researchers began using MN as a model for cGAS activation.  "However, we were excited to obtain the opposite results," says Yuki Sato at KyotoU's Graduate School of Biostudies.  Previous correlative results have also suggested that an MN-mediated innate immune response may drive cellular senescence and suppress cancer. However, Hayashi's team now feels the need to revisit this model. "Given that these findings were derived specifically from the human colon cancer cell type HCT116, we should also conduct further analyses across different cell types and species before establishing theories about the MN-activated pathway," concludes Hayashi. An artist's impression of the cGAS-STING pathway response model for the micronucleus. Previously, cGAS accumulation in micronuclei was considered an indicator of cGAS activation. Now, it was found that micronuclei are inert to cGAS. Credit:KyotoU GTobiyama/Makoto Hayashi Researcher(s) 研究者名 Makoto Hayashi Researchmap Publication information 【DOI】 https://doi.org/10.26508/lsa.202302424 【KURENAI ACCESS URL】 http://hdl.handle.net/2433/286953 Yuki Sato, Makoto T Hayashi (2024). Micronucleus is not a potent inducer of the cGAS/STING pathway. Life Science Alliance, 7(4):e202302424. 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