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入学希望の方一般・社会人の方研究者の方同窓生の方在学生の方教職員の方 日本語 (Japanese) Graduate School of Life Sciences, Tohoku University Access sitemap Link Tohoku University HOMEAbout UsAbout UsMessage from the DeanOrganizationMovieResearchLaboratories Department of Integrative Life Sciences Department of Ecological Developmental Adaptability Life Sciences Department of Molecular and Chemical Life SciencesResearchAwardEducationDegree ProgramsCourseSyllabusScheduleStudent LifeAdmissionAdmission InformationApplicationExamination Schedule and Application GuidelinesInformation Session(2024)Admission and Tuition FeesAdmission PolicyVoices from Graduates and Current StudentsAdmissions Q&AInquiries about Entrance ExaminationsFinancial SupportFor StudentsGraduate School&＃039;s Message Board for Students Information about Completion and Advancement to the Doctoral Course ProceduresCertificatesAbout Issuance of Various CertificatesNotice Regarding the Suspension of Operation of the Automatic Certificate Issuing MachinesLeave of absence/withdrawal from universityCampus Life, Various consultation servicesContactAccessLinkSitemapInformationAdmissionResearchAwardSeminarJobNewsAnnouncementOther MENU HOMEAbout UsAbout UsMessage from the DeanOrganizationMovieResearchLaboratoriesResearchAwardEducationDegree ProgramsCourseSyllabusScheduleStudent LifeAdmissionAdmission InformationApplicationExamination Schedule and Application GuidelinesInformation Session(2024)Admission and Tuition FeesAdmission PolicyVoices from Graduates and Current StudentsAdmissions Q&AInquiries about Entrance ExaminationsFinancial SupportFor StudentsGraduate School&＃039;s Message Board for Students Information about Completion and Advancement to the Doctoral Course ProceduresCertificatesLeave of absence/withdrawal from universityCampus Life, Various consultation servicesContactAccessLinkSitemapInformationAdmissionResearchAwardSeminarJobNewsAnnouncementOther 日本語 (Japanese) CLOSE Graduate School of Life Sciences, Tohoku University. Fields Molecular and Chemical Life Science :Molecular and Network Genomics Research Microbial Genetics and Evolution HOME Research Laboratories Microbial Genetics and Evolution JAPANESE Microbial Genetics and Evolution The aim of this laboratory is to elucidate the molecular mechanisms of environmental adaptation and the evolution of microbial strains and their communities from standpoints of genetics, molecular biology, genomics, and molecular ecology. Particular emphasis is placed on the environmental microbes capable of degrading various chemical pollutants. The following are major topics of our research projects: Analysis of microbial biodegradation of various recalcitrant pollutants. Analysis of mobile genetic elements involved in the degradation of various pollutants. Structural and functional genomics of environmental microbes under laboratory conditions and in natural environments. Integrative genomic analysis of environmental microbial communities under natural environments. Research Overview Our targets are microbial strains able to degrade various recalcitrant pollutants, especially aromatic and aliphatic hydrocarbons and their halogenated compounds. The microbial genes and enzymes directly and indirectly involved in this degradation have been analyzed in detail. We have demonstrated that 1) the degradation genes and their clusters are often loaded on various mobile genetic elements (MGEs) such as transposons, plasmids, and integrative and conjugative elements and 2) their intra- and intercellular movement greatly contributes to i) wide dissemination of nearly identical genes and their clusters in various phylogenetically distant microbial strains, and ii) rapid evolution of the pollutant-degrading microbes. Comparative genomic analysis of our target microbes has also definitely supported the important roles of the MGEs in the establishment of the present structures of microbial genomes. For completion of whole genome sequencing and genome comparison, we have developed our own original software programs, which are available freely to academic scientists. The programs are deposited on our website: http://www.ige.tohoku.ac.jp/joho/gmProject/gmhome.html. More than 99% of microbes in natural environments are still difficult to cultivate under laboratory conditions, meaning that we only understand a tiny fraction of the microbial world. To better understand microbial lifestyles and their potential to degrade recalcitrant compounds in the natural environment, we have clarified the environmental microbial genes that are specifically expressed and/or pivotal for survival/proliferation in the soil environment. We have also employed function- and sequence-driven metagenomic approaches to i) directly isolate and characterize genes for the degradation of pollutants, and ii) investigate the time-course response of the microbial community to pollutants in soil microcosms. For more details, please access http://www.ige.tohoku.ac.jp/joho/index.html. Some of our recent work is summarized in the Springer-Verlag book: Biodegradative Bacteria: How Bacteria Degrade, Survive, Adapt, and Evolve. (2014); Nojiri, H., M. Tsuda, M. Fukuda, and Y. Kamagata (eds). A comprehensive list of our recent papers and reviews can be found at the following URL: http://www.ige.tohoku.ac.jp/joho/labhome/publication.html. URLs http://www.lifesci.tohoku.ac.jp/biideshin/index.html Faculty Members Professor NAGATA Yuji More Biodegradation of environmental pollutants Evolution of bacterial genes and genomes Protein engineering of dehalogenases Associate Professor OTSUBO Yoshiyuki More Molecular and genetic research for elucidating catabolite control mechanisms in soil bacteria that are capable of degrading man-made chemicals of environmental concerns. Creation of software programs for various analytical purposes, including comparative genomics and finishing of microbial draft genomes. Assistant Professor STARI Leonardo More Biodegradation of chlorinated compounds, Bioremediation. Assistant Professor KISHIDA Kouhei More Horizontal gene transfer, Bacterial conjugation   ResearchLaboratories Department of Integrative Life Sciences Department of Ecological Developmental Adaptability Life Sciences Department of Molecular and Chemical Life SciencesResearchAward GO TOP Graduate School of Life SciencesTohoku University 2-1-1 Katahira, Aoba-Ku, Sendai 980-8577 Academic Affairs Section Tel : +81-22-217-5706 / Fax: +81-22-217-5704   General Affairs Section Tel : +81-22-217-5702 / Fax: +81-22-217-5704   Contact ・Privacy Policy HOMEAbout UsAbout UsMessage from the DeanOrganizationMovieResearchLaboratories Department of Integrative Life Sciences Department of Ecological Developmental Adaptability Life Sciences Department of Molecular and Chemical Life SciencesResearchAwardEducationDegree ProgramsCourseSyllabusScheduleStudent LifeAdmissionAdmission InformationApplicationExamination Schedule and Application GuidelinesInformation Session(2024)Admission and Tuition FeesAdmission PolicyVoices from Graduates and Current StudentsAdmissions Q&AInquiries about Entrance ExaminationsFinancial SupportFor StudentsGraduate School&＃039;s Message Board for Students Information about Completion and Advancement to the Doctoral Course ProceduresCertificatesAbout Issuance of Various CertificatesNotice Regarding the Suspension of Operation of the Automatic Certificate Issuing MachinesLeave of absence/withdrawal from universityCampus Life, Various consultation servicesContactAccessLinkSitemapInformationAdmissionResearchAwardSeminarJobNewsAnnouncementOther © 2004-2023 Graduate School of Life Sciences, Tohoku University no cache