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International Affairs Students Current Students Alumni Faculty/Staff Careers--> TOHOKU UNIVERSITYCREATING GLOBAL EXCELLENCE Search 日本語 Contact Tohoku University --> About Facts & Figures Facilities Organization Chart History President's Message Top Global University Project Designated National University Global Network Promotional Videos Academics Undergraduate Graduate Courses in English Exchange Programs Summer Programs Double Degree Programs Academic Calendar Syllabus Admissions Undergraduate Admissions Graduate Admissions Fees and Expenses Financial Aid Research Feature Highlights Research Releases University Research News Research Institutes Visitor Research Center Research Profiles Academic Research Staff Campus Life International Support Office IT Services Facilities Dining & Shops Campus Bus Clubs & Circles News University News Research--> Arts & Culture Health & Sports Campus & Community Press Release--> International Visit Alumni Careers Events Exhibits Music Special Event Lecture Alumni--> Map & Directions Campus Maps & Bus--> Facilities Map--> TOHOKUUNIVERSITY About Academics Admissions Research Campus Life News Events International Affairs Students Current Students Alumni Faculty/Staff Promotional Videos Subscribe to our Newsletter Map & Directions Contact Jobs & Vacancies Emergency Information Site Map 日本語 Close Home Research News Reading Chemicals Inside the Brain with an Aptamer/Microelectronic Fiber Combination Research News Reading Chemicals Inside the Brain with an Aptamer/Microelectronic Fiber Combination 2023-05-17 A research group has developed a neural device that detects specific neurotransmitters in the brain with high sensitivity and selectivity by combining multifunctional fibers and DNA molecular probes. Details of their research were published in the journal Analytical Chemistry on April 24, 2023. It is estimated that over a billion people suffer from brain disorders worldwide. Current therapeutic techniques use electrical modalities to establish an interface with the brain. This typically involves electrodes being used to read electrical potential or deliver electrical currents to specific tissues of organs in the body. However, cells inside the brain communicate with each other via chemical signals, and thus researchers have been looking for ways to measure and manipulate both the electrical and chemical signals. One such breakthrough in this regard has been microscopic, thermally-drawn microelectronic fiber-based neural probes that can act as an interface with the brain across electrical, chemical, optical, and mechanical modalities. Still, the capabilities of this technology for studying intrinsic in-brain chemistry have yet to be explored, and few attempts have studied how it could be integrated with multi-modal and multi-level brain studies. "We expanded the capabilities of the fibers to include neurochemical sensing," says Dr. Yuanyuan Guo, associate professor at Tohoku University's Frontier Research Institute for Interdisciplinary Sciences (FRIS), and leader of the research group. "We coupled aptamers, a new type of biosensor comprising a single strand of synthetic DNA with customizable sequences, on the microelectronic fibers. These defined aptamers sense neurochemicals with high sensitivity and high selectivity." The aptamer-coupled microelectrode fiber sensors (apta-μFS) for neurochemical sensing. ©T.Saizaki et al. Aptamers can be thought of as keys that specifically unlock the locks of certain target molecules. Like a key fits into a specific lock and opens it, an aptamer can bind to a specific molecule and interact with it in a selective manner. In the study, the defined aptamer sequences bound to specific molecules with a high affinity, inducing a reversible three-dimensional conformational change from a relatively simple chain structure into a complex structure wrapping around targets. Aptamers were tagged with ferrocene as an electrochemical readout for target molecule and aptamer binding. The research group focused on dopamine due to its physiological significance in mediating learning behavior and motivation. But Guo points out that this sensing mechanism is applicable to other molecules regardless of their charge or electrochemical profile. "Our discovery provides a universal method for fiber surface modification, to monitor wide-range molecules of interest." Ultimately, the breakthrough will hopefully enable the development of new brain research and methods for the prevention and treatment of diseases of the brain and organs that have not been elucidated to date. Publication Details: Title: The development of aptamer-coupled microelectrode fiber sensors (apta-μFS) for highly selective neurochemical sensingAuthors: Tomoki Saizaki, Mahiro Kubo, Yuichi Sato, Hiroya Abe, Tomokazu Ohshiro, Hajime Mushiake, Fabien Sorin and Yuanyuan GuoJournal: Analytical ChemistryDOI: 10.1021/acs.analchem.2c05046 Press release in Japanese Contact: Yuanyuan GuoEmail: yyuanguofris.tohoku.ac.jpWebsite: https://sites.google.com/view/neuroelectronics/?pli=1 Archives 2014&＃24180; 2015&＃24180; 2016&＃24180; 2017&＃24180; 2018&＃24180; 2019&＃24180; 2020&＃24180; 2021&＃24180; 2022&＃24180; 2023&＃24180; Page Top About Tohoku University Academics Admissions Research Campus Life News Events International Affairs Students Alumni Promotional Videos Subscribe to our Newsletter Map & Directions Contact Tohoku University Jobs & Vacancies Emergency Information Site Map Media Enquiries Parent & Family Support Public Facilities Contact Tohoku University