お望みのライブカジノを見つけよう - RightCasino.com

Kyoto University iCeMSInstitute for Integrated Cell-Material Sciences News Access Contact JP --> Menu アイセムスについて About Us アイセムスについてトップ More About Us アイセムスについて Papers Media Coverage INTERNATIONAL RESEARCHEREXCHANGE Academic Events Public Events Director's Vision Diversity and Inclusion Academic Cooperation & Exchange Organization Chart Research Promotion Education Timeline Access 研究について Research --> 研究についてトップ More Research 研究について Research --> 産業応用に向けて Innovation --> アイセムスの人々 People アイセムスの人々トップ More People アイセムスの人々 Principal Investigators Research Adminisration Division iCeMS Frontrunners First Author Interviews The Other Half of iCeMS Member Directory もっと知る More もっと知るトップ More More もっと知る Newsletter Photo Gallery Video Gallery Art Gallery Research Scope Brochure International Laboratories 解析センター ANALYSIS CENTER --> IG X YT Join iCeMS Support iCeMS Menu About Usアイセムスについて About Us Director's Vision Diversity and Inclusion Academic Cooperation & Exchange Organization Chart Research Promotion Education Timeline Access Innovation Past Activity Research研究について Research Research Areas Structural Coloration Body-on-a-Chip Innovation産業応用に向けて Innovation Peopleアイセムスの人々 People Principal Investigators Research Adminisration Division iCeMS Frontrunners First Author Interviews The Other Half of iCeMS Member Directory Moreもっと知る More Newsletter Photo Gallery Video Gallery Art Gallery Promotional Goods Newsletter Research Scope Brochure International Laboratories Smart Materials Research Center (VISTEC) Quantum Nano Medicine Research Center (UCLA) Center for Integrated Biosystems (Academia Sinica) Laboratory for Green Porous Materials (A*STAR-IMRE) Kyoto University Shanghai Lab (Fudan University) Center for Integrated Data-Material Sciences (MacDiarmid Institute) Small Molecule Lab (CNRS) iCeMS Taiwan Office INJA IN BIO SKAEM-JIL LATEST NEWS アイセムスで働く｜研究する Join iCeMS ご支援のお願い Support iCeMS iCeMS International Laboratories News Access Contact トップHOME > News > Research > Toward understanding sperm quality Research March 6, 2024 IG --> Toward understanding sperm quality A novel method for studying genes in testicular cells of living animals could lead to breakthroughs in male contraception and fertility treatments. The research team applied the Revival Screening method to mouse testes to identify genes involved in determining sperm quality and developed new software that enables the estimation of the molecular signaling pathways regulating these genes. (©️Mindy Takamiya/Kyoto University iCeMS) A novel screening system developed at Kyoto University enables researchers to investigate sperm cell development and health at the molecular level. The new approach, published in Cell Genomics, promises breakthroughs in male contraception and infertility treatments. The study, led by Professor Jun Suzuki of the Institute for Integrated Cell-Material Sciences (WPI-iCeMS), addresses a critical gap by directly targeting genes within testicular cells inside living organisms. Utilizing a genetic tool called CRISPR, which can be likened to genetic scissors, the researchers developed a method to investigate which genes contribute to healthy sperm production in living animals. Until now, this had mainly been done in cells cultivated in the laboratory. The researchers randomly disrupted genes by developing a method to introduce a collection of genetic tools in lentivirus into testicular cells in testes at high efficiency. Through this method, the researchers made it possible to analyze the effects of targeted genes on specific biochemical reactions in the sperm cells, such as the movement of lipids (fats) in cell membranes. Using the method, the team focused on sperms with defective capacitation, a process through which sperms become capable of fertilizing an egg. They identified these sperms by measuring how much calcium they absorbed. By using this method in live animals, they were able to identify a specific gene, Rd3, as being crucial for maintaining sperm cell health, particularly during sperm cell development. Despite Rd3’s previous association with eye function, the team found it is also highly active in round sperm cells, an early stage in sperm production, and that it plays a significant role in regulating sperm health. This discovery was made possible by examining how Rd3 interacts with mitochondria, structures responsible for energy production within cells. To further understand Rd3's function, Suzuki and his colleagues developed Hub-Explorer, a computational tool that revealed Rd3's impact on regulation of oxidative stress—a condition linked to cellular damage. Rd3's role in regulating oxidative stress revealed its significance in maintaining sperm integrity during development. “While women have many available birth control options, choices for men remain limited,” says Noguchi, a first author of this paper. “This new screening method holds promise by aiding the discovery of key molecules, potentially leading to new birth control options and infertility therapies for men.” “These discoveries not only advance our understanding of sperm cell development but also demonstrate the potential to uncover mysteries in different biological processes,” adds Suzuki. “The method can also be applied to other tissues, potentially expediting the development of drugs for a wide range of diseases.” Despite these advancements, challenges remain. The researchers observed a gradual decline in the number of cells with targeted genes, suggesting room for improvement. They are currently exploring alternative approaches to enhance the effectiveness of their technique, and they plan to apply it to investigate various biological processes and diseases in other areas of the body. Paper Information “In vivo CRISPR screening directly targeting testicular cells” Authors: Yuki Noguchi, Yasuhito Onodera, Tatsuo Miyamoto, Masahiro Maruoka, Hidetaka Kosako, Jun Suzuki Cell Genomics | DOI: 10.1016/j.xgen.2024.100510 Back Other Activities May 15, 2024 [New article available] First Author Interview: Dr Yifan Gu May 1, 2024 iCeMS and IPE Jointly Held a Symposium on Material and Environmental Science Activities April 19, 2024 iCeMS Launches New Diversity &＃038; Inclusion Desk Activities April 16, 2024 Chinese Academy of Sciences (CAS) visits iCeMS Activities March 29, 2024 The &＃8220;iCeMS Vision Book&＃8221; and &＃8220;iCeMS Concept Book&＃8221; released Activities March 19, 2024 Taiwan and Kyoto Unite: Students Spark Collaboration at the iCeMS-NTUMST Symposium Activities March 19, 2024 JSPS HOPE Meeting Participants Tour iCeMS Activities March 18, 2024 Laboratory for Green Porous Materials (LGPM) held its opening ceremony in Singapore Back アイセムスで働く｜研究する Join iCeMS ご支援のお願い Support iCeMS About Usアイセムスについて Director's Vision Diversity and Inclusion Academic Cooperation & Exchange Organization Chart Research Promotion Education Timeline Access Innovation Past Activities Research研究について Research Areas Developing Research Peopleアイセムスの人々 Principal Investigators Research Administration Division Member Directory iCeMS Frontrunners First Author Interviews The Other Half of iCeMS Moreもっと知る Photo Gallery Video Gallery Art Gallery Promotional Goods Newsletter Research Scope Brochure International Laboratories  Smart Materials Research Center (VISTEC) Quantum Nano Medicine Research Center (UCLA) Center for Integrated Biosystems (Academia Sinica) Laboratory for Green Porous Materials (A*STAR-IMRE) Kyoto University Shanghai Lab (Fudan University) Center for Integrated Data-Material Sciences (MacDiarmid Institute) Small Molecule Lab (CNRS) iCeMS Taiwan Office INJA IN BIO SKAEM-JIL LATEST NEWS Newsニュース一覧 All Research Activities Awards Living in Kyoto Terms of Use / Privacy Policy Extenal Links Member's Site Contact IG X YT Copyright © Institute for Integrated Cell-Material Sciences, Kyoto University. All rights reserved.