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--> OutlineMessageMissions & History3GeV SR FacilityOrganizationPartnersAccess & Contact ResearchersReseachers Cross Fertilization Division Next-generation detection system Smart Lab Big data Smart Lab Data visualization Smart lab International collaboration Smart lab SR Core Research Division Functional measurement Smart lab Multimodal measurement Smart lab Multiscalel measurement Smart lab Interface measurement Smart lab Spin measurement Smart lab Bio-spectroscopic measurement Smart lab Innovation and Technology Transfer Division Materials Science / Energy / Environment Smart Lab Electronics Smart Lab Future Medical / Drug Discovery Smart Lab Agriculture / Food Smart Lab Joint Research Division Synchrotron Next Generation Measurement Science Collaboration Research Division Co-creation Research Center ActivitiesCooperationAllianceOutreachPublic RelationsPhoSIC JP Close Researchers Future Medical / Drug Discovery Smart Lab Smart lab, Research department Future Medical / Drug Discovery Smart Lab Members Professor GONDA Kohsuke School of medicine Research Activities Elucidation of vascular lesions by nanomedicine and its medical application Cancer, thrombosis, and diabetes have many affected people in Japan and overseas, and it is expected to elucidate the mechanisms of these diseases and develop diagnostic and therapeutic technologies using the concepts of the disease mechanisms. Since all diseases closely relate to vascular lesions, it is important to elucidate the structure and function of blood vessels involving in the progression of these diseases and the efficacy of the drugs against the diseases. By imaging the living body and excised tissue of mouse models for cancer, thrombosis, and diabetes with high resolution and high sensitivity, we can go to the heart of problem for vascular lesions of these diseases and develop new diagnostic technologies and drugs.  We have used fluorescent nanoparticles with high brightness and nanoparticles with high X-ray absorption as probes and tracers to image with an optical microscope and µX-ray CT scanner, and have applied them to the medical applications of nanotechnology (nanomedicine). At International Center for Synchrotron Radiation Innovation Smart (SRIS), we would like to integrate these imaging technologies with synchrotron radiation imaging and develop them into new technologies as nanomedicine that promote the elucidation of vascular lesions and its medical applications. Visualization of tumor vessels. (A) In vivo tumor vessels imaged by using µX-ray CT. White show the tumor vessels with high blood flow. (B) An image of tumor tissue sliced and then fluorescently immunostained. Yellow and green show blood vessels with ResearchersReseachers Cross Fertilization Division SR Core Research Division Innovation and Technology Transfer Division Joint Research Division Co-creation Research Center Top of Page Policy Sitemap Archive © Tohoku University --> International Center for Synchrotron Radiation Innovation Smart, Tohoku University © Tohoku University @ This site uses COOKIEs to offer you a better browsing experience and to record access logs. Read more about COOKIEs. Accept all COOKIEs no cache